Search results for "intact proinsulin"

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Adding insulin glargine vs. NPH insulin to metformin results in a more efficient postprandial β-cell protection in individuals with type 2 diabetes

2010

AIM Postprandial release of intact proinsulin (IP) is an independent marker for beta-cell dysfunction in patients with type 2 diabetes. This open-label, parallel-group, two-arm, pilot study compared the beta-cell protective effect of adding insulin glargine (GLA) vs. NPH insulin to ongoing metformin. MATERIAL AND METHODS Overall, 28 insulin-naive type 2 diabetes subjects (mean +/- SD age, 61.5 +/- 6.7 years; diabetes duration, 9.8 +/- 6.5 years; HbA1c, 7.1 +/- 0.5%; BMI, 30.7 +/- 4.3 kg/m(2)) treated with metformin and sulfonylurea were randomized to add once-daily GLA or NPH at bedtime. At baseline and after 3 months, subjects received a standardized breakfast, lunch and dinner, with pre- …

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Investigation of insulin resistance in narcoleptic patients: dependent or independent of body mass index?

2011

Alice Engel1,2, Jana Helfrich1, Nina Manderscheid1, Petra B Musholt3, Thomas Forst3, Andreas Pfützner3, Norbert Dahmen1,21Department of Psychiatry, University of Mainz, Germany; 2Fachklinik Katzenelnbogen, Katzenelnbogen, Germany; 3IKFE, Institute for Clinical Research and Development, Mainz, GermanyBackground: Narcolepsy is a severe sleep-wake cycle disorder resulting in most cases from a lack of orexin, the energy balance-regulating hormone. Narcoleptic patients have been reported to suffer from an excess morbidity of Type 2 diabetes, even after correction for their often elevated body mass index.Methods: To explore whether narcolepsy is specifically associated with a propensity …

insulinobesitymedicine.medical_specialtyPathologyNeuropsychiatric Disease and Treatmentmedicine.medical_treatmentnarcolepsyNeurosciences. Biological psychiatry. NeuropsychiatryType 2 diabetesInsulin resistanceInternal medicinemedicineintact proinsulinRC346-429Biological PsychiatryOriginal ResearchProinsulinbusiness.industryInsulinmedicine.diseaseOrexinPsychiatry and Mental healthEndocrinologyHomeostatic model assessmentNeurology. Diseases of the nervous systemfasting glucosebusinessBody mass indexRC321-571NarcolepsyNeuropsychiatric Disease and Treatment
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